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Objectives: To conduct a systematic review and meta-analysis regarding the efficacy and safety of inhaled corticosteroids for COPD exacerbations. Patients and Methods: MEDLINE, EMBASE, PsychINFO, and CINAHL were searched from inception to January 2010, prohormones.co.uk review. Randomized controlled trials included patients with active COPD (COPD ≥2 months; defined as ≥10/min arterial pressure, or ≥20% decreased oxygen saturation) at the start of the study. Results: All included systematic reviews had been completed, providing 6 trials, 1 with a pooled analysis including 1849 participants, top rated prohormone supplements. Randomized controlled trials examining the effect of inhaled corticosteroids on symptomatic and functional COPD exacerbations were more likely to include patients with higher baseline levels of pulmonary inflammation. However, inhalation of higher levels of corticosteroids was associated with poorer respiratory function and increased risks for pneumonia compared with lower doses. Conclusions: This review suggests that the most common dose for inhaled corticosteroids is 10mg per day, review prohormones.co.uk. The dose of steroids in asthma treatment is increasing because of the need to reduce doses in many populations. While some studies suggest inhaled corticosteroids are associated with improvements in pulmonary function, other studies have not demonstrated such effects, top 10 prohormones. However, these data provide some evidence of the efficacy of bronchodilator therapy in patients with acute exacerbations of COPD. The long-term safety of inhalation of steroids is also unknown.
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